منابع مشابه
Mathematical modeling of polyamine metabolism in mammals.
Polyamines are considered as essential compounds in living cells, since they are involved in cell proliferation, transcription, and translation processes. Furthermore, polyamine homeostasis is necessary to cell survival, and its deregulation is involved in relevant processes, such as cancer and neurodegenerative disorders. Great efforts have been made to elucidate the nature of polyamine homeos...
متن کاملMathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis.
Low-folate status and genetic polymorphisms in folate metabolism have been linked to several cancers. Possible biological mechanisms for this association include effects on purine and thymidine synthesis, DNA methylation, or homocysteine concentrations. The influence of genetic variation in folate metabolism on these putative mechanisms or biomarkers of cancer risk has been largely unexplored. ...
متن کاملFolate Metabolism and Preeclampsia
1OMNI Research Group, Department of Obstetrics and Gynecology, University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada. 2Ottawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa, Ontario, Canada. 3School of Public Health, Central South University, Changsha, Hunan, PRC. 4Huaihua Medical College, Huaihua, Hunan, PRC. 5Queen’s Perinatal Research Unit, Department of Obst...
متن کاملMathematical Modeling of Plant Metabolism―From Reconstruction to Prediction
Due to their sessile lifestyle, plants are exposed to a large set of environmental cues. In order to cope with changes in environmental conditions a multitude of complex strategies to regulate metabolism has evolved. The complexity is mainly attributed to interlaced regulatory circuits between genes, proteins and metabolites and a high degree of cellular compartmentalization. The genetic model ...
متن کاملA mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism.
Impaired folate-mediated 1-carbon metabolism has been linked to multiple disease outcomes. A better understanding of the nutritional and genetic influences on this complex biochemical pathway is needed to comprehend their impact on human health. To this end, we created a mathematical model of folate-mediated 1-carbon metabolism. The model uses published data on folate enzyme kinetics and regula...
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ژورنال
عنوان ژورنال: Wiley Interdisciplinary Reviews: Systems Biology and Medicine
سال: 2013
ISSN: 1939-5094
DOI: 10.1002/wsbm.1227